1 00:00:00,000 --> 00:00:11,252 This series presents information based in part on theory and conjecture. 2 00:00:11,252 --> 00:00:15,855 The producer's purpose is to suggest some possible explanations, but not necessarily 3 00:00:15,855 --> 00:00:22,101 the only ones to the mysteries we will examine. 4 00:00:22,101 --> 00:00:30,107 Biologists have patched together the genes of six mice to produce this single offspring. 5 00:00:30,107 --> 00:00:35,511 More astonishing is the mouse created from only one parent. 6 00:00:35,511 --> 00:00:48,522 One day, it may become possible to make exact replicas of human beings. 7 00:00:49,523 --> 00:00:55,528 The chance of twins being born is about one in eighty. 8 00:00:55,528 --> 00:01:00,532 The likelihood that they be identical is less than one in two hundred. 9 00:01:00,532 --> 00:01:09,539 Wherever they appear, they are startling and fascinating. 10 00:01:09,539 --> 00:01:19,547 But if twins are rare, the odds against identical triplets are astronomical. 11 00:01:19,547 --> 00:01:25,552 These boys are lucky to have been born in the twentieth century. 12 00:01:25,552 --> 00:01:34,559 Among primitive peoples, twins and triplets were feared and rejected. 13 00:01:34,559 --> 00:01:41,565 Mother bearing such an animal like litter was thought to be a cursed. 14 00:01:41,565 --> 00:01:45,568 One or all of the children were frequently killed. 15 00:01:45,568 --> 00:01:54,575 Today, such children are nature's oddity, but in the near future they could become a familiar sight. 16 00:01:54,575 --> 00:02:02,582 There's a good chance that science will learn how to create identical human beings, or clones, as they are called. 17 00:02:02,582 --> 00:02:10,588 In both intrigues and alarms people, there's a feeling that people created by laboratory manipulation would be less than human. 18 00:02:10,588 --> 00:02:14,592 A sense that something evil may be on the horizon. 19 00:02:14,592 --> 00:02:22,598 Biologically, however, clones would be much like identical twins, triplets, or quadruplets. 20 00:02:22,598 --> 00:02:32,606 These ten-year-olds form one of a dozen sets of identical quadruplets in the country. 21 00:02:32,606 --> 00:02:42,614 The boys do look remarkably alike, though there are differences, and more will become apparent as they get older. 22 00:02:43,615 --> 00:02:54,624 Their physical similarity and emotional closeness often blinds people to the fact that genetic identicles are separate individuals. 23 00:02:54,624 --> 00:03:01,630 They may look alike, but they do not necessarily think or act alike. 24 00:03:01,630 --> 00:03:07,635 Well, it's very close, and there's a very, very strong bond. 25 00:03:07,635 --> 00:03:16,642 And I just can't describe it to you very much alike, and then we also differ a great deal. 26 00:03:16,642 --> 00:03:25,649 Our personalities are entirely different, and emotionally, possibly my sister is the stronger the two of us. 27 00:03:25,649 --> 00:03:32,655 Physically, I say my sister is stronger than I am. She moves quicker. 28 00:03:32,655 --> 00:03:44,665 My sister does it in a very big manner and much more action, maybe a little more noise. 29 00:03:44,665 --> 00:03:52,671 This is Robin. He has a thinner face, and this is Ray. He has a wider jaws and wider face. 30 00:03:52,671 --> 00:03:56,674 Rich has a rounder head. 31 00:03:56,674 --> 00:04:06,682 They walk and run completely different, and then their body is different. It's three different kids. 32 00:04:06,682 --> 00:04:13,688 The Bearning Twins are one of two pairs of identical twin gynecologists in the country. 33 00:04:13,688 --> 00:04:21,695 I think I'm a little more sedate, a little more likely to let nature take its course, whereas my brother is a little more aggressive, 34 00:04:21,695 --> 00:04:29,701 a little more likely to rock the boat and get a little upset a little more quickly than I do. 35 00:04:29,701 --> 00:04:37,708 Perfocative, or maybe volatile, is the word that I like to use. 36 00:04:37,708 --> 00:04:45,714 Twins are not clones, but they are living examples of what clones could be. 37 00:04:45,714 --> 00:04:58,725 If we are to rise above the superstition of primitive tribes who killed twins, we must not think of clones as either less or more than human. 38 00:04:58,725 --> 00:05:09,734 Genetically, a pair of human clones would be the same as a pair of identical twins. They would, however, not originate in the same way. 39 00:05:09,734 --> 00:05:22,744 The conception of a normal baby begins with an egg from the mother, which carries her genetic instructions and with sperm from the father, carrying his genetic makeup. 40 00:05:22,744 --> 00:05:35,755 When the sperm fertilizes the egg, the genetic information from the father joins that from the mother, and the cell begins to divide. 41 00:05:35,755 --> 00:05:53,769 Occasionally, the cell mass splits apart at an early stage. The separate halves continue dividing. They become identical twins, alike down to tiny details of face, hair, and teeth. 42 00:05:53,769 --> 00:06:04,778 It is believed that a person's skin and other body cells carry all the genetic instructions needed to duplicate that person. 43 00:06:04,778 --> 00:06:12,785 The process of cloning someone would begin with any one of their cells and any fertilized human egg. 44 00:06:12,785 --> 00:06:21,792 The egg nucleus containing its genetic instructions would be removed, and the nucleus from the donor cell inserted. 45 00:06:21,792 --> 00:06:29,798 After implantation in any woman's womb, the altered egg would divide and grow in the usual way. 46 00:06:29,798 --> 00:06:43,810 It would become the younger identical twin of the original cell donor, his or her clone. 47 00:06:43,810 --> 00:06:55,820 All of this is theoretically understood. Human cloning may be possible. But for lower forms of life, cloning is a reality. 48 00:06:55,820 --> 00:07:05,828 Some orchids clone themselves naturally. Others need a little help from man. 49 00:07:05,828 --> 00:07:15,836 At the Rod McClellan Company, south of San Francisco, growers are in the business of cloning beauty. 50 00:07:15,836 --> 00:07:26,845 They cut a tiny sliver of cells from the shoot of a mature plant and put the pieces in nutrient. 51 00:07:26,845 --> 00:07:32,850 After weeks of constant agitation, the cells grow into green clumps. 52 00:07:32,850 --> 00:07:37,854 The clumps grow into orchid plants exactly like the original. 53 00:07:37,854 --> 00:07:46,861 The process assures the growers that every orchid plant will be healthy and bear top quality flowers. 54 00:07:46,861 --> 00:07:50,864 Cloning techniques are also being applied to trees. 55 00:07:50,864 --> 00:07:57,870 In California, the original stands of the giant redwood are rapidly disappearing. 56 00:07:57,870 --> 00:08:07,878 Researchers are helping reforest with a new breed of trees, faster growing, straighter redwoods with fewer branches than their ancestors. 57 00:08:07,878 --> 00:08:17,886 The breeding of super trees begins with the selection of the best tree in a stand. 58 00:08:17,886 --> 00:08:27,894 Twigs from the top of the tree are shot down and carefully gathered. 59 00:08:27,894 --> 00:08:31,897 Carbon copy redwoods are then grown in test tubes. 60 00:08:31,897 --> 00:08:39,904 Pieces of twig are planted in a special nutrient containing sugar, minerals, and growth-promoting hormones. 61 00:08:39,904 --> 00:08:45,909 Within a few months, a batch of little cloned trees is ready for planting in the nursery. 62 00:08:45,909 --> 00:08:54,916 In a year, reforestation can begin. 63 00:08:54,916 --> 00:09:00,921 In the last decade, cloning research has made awesome strides. 64 00:09:00,921 --> 00:09:12,931 Biologists use the cells of one axolotl, a large Mexican salamander, to create its clones. 65 00:09:12,931 --> 00:09:15,933 Eggs are taken from a white axolotl. 66 00:09:15,933 --> 00:09:21,938 Normally, they would be fertilized by different sperm and grown into different axolotls. 67 00:09:21,938 --> 00:09:24,940 But a stranger fate awaits these eggs. 68 00:09:24,940 --> 00:09:27,943 Their genetic information is destroyed. 69 00:09:27,943 --> 00:09:37,951 They will become carriers for genetic instructions from other axolotl cells. 70 00:09:37,951 --> 00:09:42,955 A spotted axolotl embryo becomes the source of these cells. 71 00:09:42,955 --> 00:09:49,961 It is picked apart into individual cells. 72 00:09:49,961 --> 00:09:53,964 What comes next is the very essence of animal cloning. 73 00:09:53,964 --> 00:10:00,970 The genetic information carrying nucleus of a cell is drawn into the pipette. 74 00:10:00,970 --> 00:10:07,975 The nucleus is transplanted into the unfertilized egg. 75 00:10:07,975 --> 00:10:15,982 Other cells from the same embryo, each carrying identical genetic instructions, can also be inserted in eggs. 76 00:10:15,982 --> 00:10:21,987 The results will be clones. 77 00:10:31,995 --> 00:10:34,997 The baby axolotls are born identical. 78 00:10:34,997 --> 00:10:36,999 Spot for spot. 79 00:10:36,999 --> 00:10:43,004 Man-made clones of a single parent. 80 00:10:43,004 --> 00:10:50,009 If cloning were achieved for man, a single individual could create descendants in his own image. 81 00:10:50,009 --> 00:10:57,015 Extraordinary people might be copied in hope of benefiting society. 82 00:10:57,015 --> 00:11:01,018 The process raises a frightful specter of individuality lost. 83 00:11:01,018 --> 00:11:06,022 It would be theoretically possible to produce an army of identical humans 84 00:11:06,022 --> 00:11:13,028 who might synchronize their brains, thoughts, and actions to become a master race. 85 00:11:20,034 --> 00:11:26,038 If human cloning became reality, a person could create his own younger identical twin. 86 00:11:26,038 --> 00:11:31,042 The prospect conjures up visions of a dozen identical prize athletes 87 00:11:31,042 --> 00:11:37,047 or a hundred facsimiles of some movie screen goddess. 88 00:11:37,047 --> 00:11:41,051 Human cloning, however, is not yet upon us. 89 00:11:41,051 --> 00:11:47,055 When biologists tried to use on mammals cloning methods developed for salamanders and frogs, 90 00:11:47,055 --> 00:11:53,060 they encountered formidable obstacles. 91 00:11:53,060 --> 00:11:59,065 Mouse or human eggs are delicate specks, much smaller than axolotl eggs. 92 00:11:59,065 --> 00:12:06,071 The operations of microsurgery can easily damage them. 93 00:12:06,071 --> 00:12:11,075 Dr. Clem Markert of Yale University is a pioneer in cloning research. 94 00:12:11,075 --> 00:12:20,082 His latest achievement is the creation of a mouse which has six parents. 95 00:12:20,082 --> 00:12:25,086 Starting with three pairs of normally mated mice, each with different coat color, 96 00:12:25,086 --> 00:12:32,092 Dr. Markert produced a three-colored patchwork female. 97 00:12:32,092 --> 00:12:42,100 This laboratory miracle was performed by putting together embryonic cells from the three matings. 98 00:12:42,100 --> 00:12:47,104 After joining, the cell groups synchronize, develop normally, 99 00:12:47,104 --> 00:12:52,108 and become one mouse instead of three. 100 00:12:52,108 --> 00:12:57,112 No one has ever cloned a mammal, but a few individuals at least have tried. 101 00:12:57,112 --> 00:13:01,115 And we're trying to develop the techniques for cloning mice right now, 102 00:13:01,115 --> 00:13:05,119 and there are two different methods that we can use in attempting to clone mice, 103 00:13:05,119 --> 00:13:10,123 both of which involve a kind of microsurgery on mouse eggs. 104 00:13:10,123 --> 00:13:15,127 The process begins with a female whose eggs have been fertilized in the normal way. 105 00:13:15,127 --> 00:13:23,133 Her eggs are collected and prepared for microsurgery. 106 00:13:23,133 --> 00:13:29,138 At this early stage, genetic material from egg and sperm have not yet mixed. 107 00:13:29,138 --> 00:13:35,143 The mothers and fathers genes are in two distinct sacs called pronuclei. 108 00:13:35,143 --> 00:13:40,147 Dr. Markert deftly removes one of the pronuclei. 109 00:13:45,151 --> 00:14:00,163 In the incubator, the remaining pronuclei replicates, 110 00:14:00,163 --> 00:14:07,169 restoring the normal amount of genetic material to the egg. 111 00:14:07,169 --> 00:14:10,171 It can now develop like any other mouse egg. 112 00:14:10,171 --> 00:14:16,176 A technician inserts the egg into the womb of a mouse who will bring it to term. 113 00:14:16,176 --> 00:14:20,180 When born, it will be a new type of animal. 114 00:14:20,180 --> 00:14:26,184 A female mouse descended from only one parent. 115 00:14:26,184 --> 00:14:30,188 But if the same steps were carried out for the next generation, 116 00:14:30,188 --> 00:14:38,194 science would produce cloned mice. 117 00:14:38,194 --> 00:14:42,197 If we repeat the procedure, then we would make clones of mice. 118 00:14:42,197 --> 00:14:47,201 And there's no technical or biological barrier to doing that right now. 119 00:14:47,201 --> 00:14:51,205 Experiments with single-parent mice are continuing. 120 00:14:51,205 --> 00:15:01,213 Within a few years, Dr. Markert expects the first cloned female mice to be made by this indirect technique. 121 00:15:01,213 --> 00:15:08,218 If cattle could be cloned by first making single-parent cows, the economic gain would be enormous. 122 00:15:08,218 --> 00:15:13,223 Dairy farmers could build whole herds of identical prized cows. 123 00:15:13,223 --> 00:15:21,229 Unlike humans, however, these animals have been bred to eliminate genetic defects. 124 00:15:21,229 --> 00:15:27,234 Human beings all carry a substantial burden of what we call recessive lethal genes, 125 00:15:27,234 --> 00:15:31,237 which if present in duplicate would cause us to die. 126 00:15:31,237 --> 00:15:36,241 So that if you began with a human egg and treated it the way we do the mouse egg, 127 00:15:36,241 --> 00:15:40,244 instead of it living and developing, it would surely die in nearly every case. 128 00:15:40,244 --> 00:15:45,248 Scientists, however, are working on another way to clone mammals, 129 00:15:45,248 --> 00:15:49,252 a method like that used to clone axolotl embryos. 130 00:15:49,252 --> 00:15:54,256 The second method involves putting a nucleus into the egg after you've previously taken its own nucleus out. 131 00:15:54,256 --> 00:15:59,260 This is more difficult. I can do this mechanically. I can insert the nucleus alright. 132 00:15:59,260 --> 00:16:03,263 The egg seems to heal up, but none of these have ever developed. 133 00:16:06,265 --> 00:16:13,271 What Dr. Markert is trying to do for the mouse has not yet been done for the axolotl. 134 00:16:13,271 --> 00:16:19,276 To begin with body cells from an adult animal and make an adult clone. 135 00:16:19,276 --> 00:16:26,282 The successful experiments with frogs and salamanders all begin with tadpoles and embryos, not adults. 136 00:16:26,282 --> 00:16:29,284 No adult animal has ever been cloned. 137 00:16:29,284 --> 00:16:35,289 But even if this barrier is hurtled, the road to human cloning presents obstacles of its own. 138 00:16:37,291 --> 00:16:41,294 The technical and logistic problems would be enormously magnified. 139 00:16:41,294 --> 00:16:46,298 I work with dozens or hundreds of mouse eggs, most of which are going to die. 140 00:16:46,298 --> 00:16:50,301 To try to do anything like that with human beings would be very difficult. 141 00:16:53,304 --> 00:16:58,308 The notion of cloning, especially cloning human beings, certainly agitates people. 142 00:16:58,308 --> 00:17:06,314 If one were successful in cloning, say, an adult man, all you would in effect do would be to produce an identical twin of that man, 143 00:17:06,314 --> 00:17:08,316 but of a very different age. 144 00:17:08,316 --> 00:17:11,318 Now there are thousands of identical twins walking around on the surface of the earth. 145 00:17:11,318 --> 00:17:13,320 They all constitute small clones. 146 00:17:13,320 --> 00:17:21,326 And to produce another set of identical twins of different age doesn't seem to me to be anything that should agitate people. 147 00:17:22,327 --> 00:17:26,330 Identicals, however, may be more special than we realize. 148 00:17:26,330 --> 00:17:32,335 Even if we were thousands of miles apart, I could feel something coming on. 149 00:17:32,335 --> 00:17:35,338 I'd pick up the phone and my answer would be right there. 150 00:17:36,338 --> 00:17:43,344 And sister would have her, she'd be ill or in some kind of trouble. 151 00:17:43,344 --> 00:17:47,347 And we can always feel this. 152 00:17:49,349 --> 00:17:51,351 We can read each other's minds. 153 00:17:51,351 --> 00:17:54,353 It's very strong, very strong. 154 00:17:55,354 --> 00:17:59,357 I think that they have the same brain thoughts, same ways. 155 00:17:59,357 --> 00:18:01,359 They come up with the same answers. 156 00:18:01,359 --> 00:18:05,362 I really believe that they think about each other the same thought at the same time. 157 00:18:07,364 --> 00:18:17,372 If there were four or five or six of us seeing that we twins are double-power, it would have been just absolutely marvelous. 158 00:18:19,373 --> 00:18:24,377 I think four or six would be a very good landslide. 159 00:18:24,377 --> 00:18:31,383 We have a veritable clinic and we have the whole town to ourselves probably. 160 00:18:31,383 --> 00:18:36,387 I'm not too worried about negative results from phoning. 161 00:18:37,388 --> 00:18:44,394 I think it's a good thing that we are able to improve the human race, if you will, 162 00:18:44,394 --> 00:18:57,404 and improve certain characteristics maybe that are desirable and eliminate undesirable individuals and characteristics, 163 00:18:57,404 --> 00:19:04,410 even though it may sound a little dangerous, depending on who calls the shots. 164 00:19:07,412 --> 00:19:11,415 Many people are afraid that if the phoning of human beings became possible, 165 00:19:11,415 --> 00:19:16,420 that the government would direct the process and produce individuals to the government's taste. 166 00:19:16,420 --> 00:19:20,423 What governments are interested in is the adult personality. 167 00:19:20,423 --> 00:19:23,425 If you were to clone individuals, you'd still just begin with a group of children, 168 00:19:23,425 --> 00:19:27,428 the same genetic makeup as some preceding generation of adults, 169 00:19:27,428 --> 00:19:32,433 but you'd still have exactly the same problems of trying to discipline them, educate them, 170 00:19:32,433 --> 00:19:36,436 change them, or make them into the kind of adults you wanted to make them into. 171 00:19:37,437 --> 00:19:43,441 One of the reasons why many people are very worried about the possibility of cloning human beings 172 00:19:43,441 --> 00:19:49,446 is that they suffer from the illusion that genes determine character, and that's just not true. 173 00:19:52,449 --> 00:19:57,453 Dr. Markert and associates are continuing attempts to clone mice. 174 00:19:57,453 --> 00:20:02,457 Their progress, manipulating eggs, has attracted new researchers to the field, 175 00:20:02,457 --> 00:20:05,459 multiplying the chances of success. 176 00:20:07,461 --> 00:20:11,464 The cloning of human beings could soon be within reach. 177 00:20:11,464 --> 00:20:16,468 If human cloning comes, serious questions will have to be faced. 178 00:20:16,468 --> 00:20:19,471 Who will be singled out for duplication? 179 00:20:19,471 --> 00:20:22,473 Who will decide how many copies to make? 180 00:20:24,475 --> 00:20:28,478 Geneticists believe that intelligence is in part inherited. 181 00:20:29,479 --> 00:20:35,484 By cloning talented individuals, society could boost the mental power of the species. 182 00:20:35,484 --> 00:20:39,487 It is a prospect at once frightening and tantalizing. 183 00:20:39,487 --> 00:20:46,493 Whether used wisely or not, cloning could profoundly alter our destiny in the universe. 184 00:20:47,493 --> 00:20:52,497 If achieved, cloning would create genetically identical individuals. 185 00:20:52,497 --> 00:20:59,503 But if cloning became a common method of human reproduction, certain types might be overbred, 186 00:20:59,503 --> 00:21:04,507 and variety is essential to the survival and evolution of a species. 187 00:21:04,507 --> 00:21:10,512 Unless carefully controlled, cloning could potentially lead us toward evolutionary disease. 188 00:21:10,512 --> 00:21:17,518 Unless carefully controlled, cloning could potentially lead us toward evolutionary disaster.